Principal AI Engineer

Principal AI Engineer

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Key Responsibilities

• Design, build, and deploy autonomous multi-agent workflows using orchestration frameworks such as LangGraph, CrewAI, Autogen, or similar, including complex state machines with conditional routing, parallel execution, and error recovery patterns.

• Architect graph-based agent workflows with 10+ nodes involving agent collaboration, task decomposition, and sequential/parallel execution across multiple business domains.

• Develop and maintain reusable agent node libraries, extensible platform patterns, versioning strategies, and testing frameworks (unit, integration, and end-to-end) for agent workflows.

• Build production-grade FastAPI applications with async I/O patterns, integrating PostgreSQL, Redis, and external enterprise services.

• Implement real-time agent streaming using Server-Sent Events (SSE) and WebSocket protocols, alongside RESTful and event-driven API architectures for agent orchestration.

• Integrate cloud-based LLM providers (AWS Bedrock, Azure OpenAI, Anthropic Claude, OpenAI GPT-4) and design prompt management systems with versioning, templating, and dynamic compilation.

• Implement conversation state persistence using Redis checkpointing and build tool-calling protocols (Model Context Protocol, function calling) for external data sources and APIs.

• Develop hybrid intelligence patterns combining LLM reasoning with rule-based logic and statistical analysis, and build response transformation pipelines for structured analytical outputs.

• Integrate observability platforms (Langfuse, LangSmith, or similar) to enable end-to-end agent tracing, telemetry, performance monitoring, and cost optimization across production workflows.

• Implement evaluation frameworks measuring agent success rates, reasoning quality, and output accuracy, while continuously optimizing token usage and LLM costs.

• Ensure enterprise security integration (LDAP, SSO, access control), robust error handling, and compliance with data governance and Responsible AI standards.

• Partner with data engineers, business analysts, and UX teams to translate requirements into scalable agent workflows and streaming interfaces.

• Mentor junior engineers on async Python patterns, agent design, and LLMOps best practices; participate in architecture reviews and contribute to documentation and knowledge sharing.

Qualifications & Experience:

· Bachelor's or Master's degree in Computer Science, AI/ML, Engineering, Data Science, or a related discipline.

· 9+ years of software engineering experience, with 2+ years building and deploying production LLM-powered applications.

· Proven experience with:

• Agentic orchestration frameworks: LangGraph (preferred), LangChain, CrewAI, Autogen, or similar.
• Cloud LLM providers: AWS Bedrock, Azure OpenAI, Anthropic Claude, or OpenAI GPT-4.
• Production async web frameworks, particularly FastAPI.
• Docker containerization, Git version control, and CI/CD pipelines.
• Cloud platforms: AWS, Azure, or Google Cloud.

· Expert-level async Python programming (asyncio, async/await patterns).

· Demonstrated experience building autonomous agent systems performing multi-step tasks beyond simple chatbots, including conditional logic, state management, and tool-calling patterns.

· Strong understanding of agentic design patterns including ReAct, Plan-and-Execute, and tool-use agents.

· Experience implementing Model Context Protocol (MCP) and agent-to-agent (A2A) communication frameworks.

· Familiarity with LLMOps practices, observability tooling (Langfuse, LangSmith), and prompt engineering at scale (templating, versioning, optimization).

· Excellent analytical, problem-solving, and communication skills with the ability to work effectively in globally distributed teams.

· Prior experience in global life sciences, especially in the GPS functional area, is a plus.

· Experience managing or collaborating with offshore technical development teams and diverse international stakeholders is a plus.

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only:  If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at TAEnablement@bms.com with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1604473 : Principal AI Engineer

Experience Level

Senior Level